Document Type

Flyer

Seminar Series : Folding biomimetic peptoid polymers into protein-like nanostructures

Authors

University of Maine Department of Chemistry

Publication Date

11-7-2024

Abstract/ Summary

A longstanding challenge in molecular biomimicry is to build synthetic nanostructures with the same architectural sophistication as proteins. One of the most promising approaches is to synthesize sequence-defined, non-natural polymer chains that, like in Nature, spontaneously fold and assemble into precise three-dimensional structures. 30 years ago, this was a daunting synthetic problem, but with the advent of the automated solid-phase submonomer synthesis method for peptoids in 1992, we can now efficiently synthesize high-purity, sequence-defined peptoid polymers up to and beyond 50 monomers in length. The method uses readily available primary amine synthons, allowing hundreds of chemically diverse side chains to be cheaply introduced.

Repository Citation

University of Maine Department of Chemistry, "Seminar Series : Folding biomimetic peptoid polymers into protein-like nanostructures" (2024). General University of Maine Publications. 3591.
https://digitalcommons.library.umaine.edu/univ_publications/3591

Version

publisher's version of the published document

Rights and Access Note

This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. In addition, no permission is required from the rights-holder(s) for non-commercial uses. For other uses, you need to obtain permission from the rights-holder(s). For more information, contact Special Collections.