The Maine-Syracuse Longitudinal Study is a study of cardiovascular risk factors in relation to cognitive performance. This 38-year study was begun by Professor Merrill F. Elias and physician David HP Streeten at Syracuse University in 1974. It has continued for 36 years at the University of Maine under the direction of Professors Elias and Robbins with many years of support by the National Institutes of Health (NIA and NHLBI). The MSLS has a rich data base. There are from one to seven longitudinal waves of data available for over 2000 participants on risk factors for cardiovascular disease and clinical cognitive performance measures. Recent waves of the study include many psychosocial variables, demographic variables, information on medications (including psychotropics), and extensive data on cardiovascular risk factors and events such as diabetes, stroke, obesity, smoking, homocysteine, APOE e4 genotype, nutrition, and self-reported activity level. The data base is open for research to UMaine faculty and students as well as investigators at other institutions who are approved by the study directors and MSLS research committee and meet NIH and University of Maine requirements for research.