Date of Award

Summer 8-29-2025

Level of Access Assigned by Author

Open-Access Thesis

Degree Name

Master of Science in Biomedical Engineering

Department

Biomedical Engineering

First Committee Advisor

Caitlin Howell

Second Committee Member

Mehdi Tajvidi

Third Committee Member

William DeSisito

Abstract

The use of harsh formaldehyde-based chemicals in some wood composite adhesives has prompted exploration of mycelial materials as a more eco-friendly friendly alternative binder. However, a key challenge in using mycelium as an adhesive is its slow growth, which typically spans several days or weeks. Here, we investigate whether vascular-inspired channels could enhance mycelial growth by improving access to oxygen and moisture. Mimicking leaf vein structures, we embedded parallel channels into mycelial substrates using 3D-printed molds to facilitate internal transport. Growth rates were tracked over time using image analysis methods to compare outcomes across experimental conditions. The results showed that increased air and moisture access significantly increased growth rates. However, when air and moisture were introduced via active flow through embedded channels, drying became an issue that slowed growth. These findings highlight the importance of controlled moisture and oxygen delivery in optimizing mycelial growth, offering valuable insights for improving the feasibility and performance of mycelium-based adhesive and materials. However, care must be taken when using active flow, as excessive airflow can lead to drying of the substrate and inhibit growth.

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