Date of Award
Summer 8-9-2018
Level of Access Assigned by Author
Open-Access Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
Advisor
William M. Gramlich
Second Committee Member
Barbara J.W. Cole
Third Committee Member
Carl P. Tripp
Additional Committee Members
Matthew Brichacek
Michael D. Mason
Abstract
Hydrogels are 3D polymeric networks with high water content and are widely being investigated for biomedical applications such as tissue engineering. Polysaccharides have been used to fabricate hydrogels due to their natural abundance, biocompatibility, and immunogeniety. Additionally, polysaccharide-based hydrogels can provide mechanical and biological cues similar to those of the natural environments. In this work, thiol-norbornene chemistry was used to fabricate polysaccharide-based hydrogels including hyaluronic acid (HA), carboxymethyl cellulose (CMC), and cellulose nanofibrils (CNFs). Hydrogels with tunable physical and mechanical properties were achieved. The properties of these hydrogels were spatiotemporally modified by photopatterning. Also, high stem cell viability was achieved when cells were encapsulated in these hydrogels.
Recommended Citation
Dadoo, Nayereh, "Chemically Cross-Linked Polysaccharide-Based Hydrogels via Thiol-Norbornene Reaction as Sustainable Biomaterials" (2018). Electronic Theses and Dissertations. 2938.
https://digitalcommons.library.umaine.edu/etd/2938