Document Type

Article

Publication Title

Nephrology Dialysis Transplantation

Publisher

Oxford UniversityPress on behalf of European Renal Association – European Dialysis and Transplant Association

Publication Date

2009

First Page

1

Last Page

7

Abstract/ Summary

Background. Non-dialysis-dependent chronic kidney dis- ease (CKD) is related to cognitive impairment. Previous studies have not explored the extent of impairment across multiple cognitive domains. We examined the range of specific cognitive abilities affected by CKD and whether the associations of CKD with cognition were eliminated by statistical control for cardiovascular disease correlates of CKD. Methods. We performed a community-based cross-sectional study with 923 individuals free from dementia and end-stage renal disease. Two groups were defined based on estimated glomerular filtration rate (eGFR): eGFR/min/1.73 m2 versus eGFR≥60 mL/min/1.73 m2. Out- come measures were scores from multiple clinical tests of specific cognitive abilities. The GFR classifications and serum creatinine levels were related to measures of cognitive performance using logistic and linear regression analyses with three sets of covariates: (1) basic(age, education, gender and race); (2) basic+risk factors for cardiovascular disease(CVD)and(3) basic+riskfactorsforCVD+stroke. Results. AneGFR<60mL/min/1.73m2 was presentin142 (15.4%) individuals; the mean (SD) eGFR in this subgroup was49.7(10.7).CKD was related to lower cognitive performance despite adjustment for CVD risk factors (CVD-RF). Adjusting for CVD-RF and stroke, odds ratios and 95% confidence intervals associated with performing in the lowest quartile of the distribution of the Global, Visual–Spatial Organization/Memory and Scanning and Tracking scores for the eGFR < 60 group were 1.97 (1.25, 3.10); 1.88 (1.21, 2.93) and 1.83 (1.56, 2.87), P < 0.01 with eGFR≥ 60 group as the reference group. Conclusions. Global performance and specific cognitive functions are negatively affected early in CKD. Targeted screening for cognitive deficits in kidney disease patients early in their disease course may be warranted.

Publisher Statement

Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

DOI

10.1093/ndt/gfp107

Version

post-print (i.e. final draft post-refereeing with all author corrections and edits)

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