Date of Award
Level of Access
Master of Science (MS)
Electrical and Computer Engineering
David E. Kotecki
Second Committee Member
Third Committee Member
The detection and identification of a particle transported in an aqueous solution through a nanopore (< l0nm opening in a thin dielectric membrane) is of technological importance and has various applications. For example, in a DNA nano-sequencer, an electrical signal is generated when a single strand of DNA passes through the nanopore. This signal is amplified by a transimpedance amplifier, then converted to a digital signal representing one of the four possible bases in the DNA. There are many challenges in implementing this sequencer. One of the challenges is to design a transimpedance amplifier with sufficient bandwidth and sensitivity to correctly identify each nucleotide. In this work the I-V characteristics of a solid-state nanopore are determined. A low-noise transimpedance amplifier was designed to increase the magnitude of the electrical signals for further signal analysis. The transimpedance amplifier, designed in 240nm IBM BiCMOS process, has an input capacitance of 250fF, a gain of 120dBf2, a bandwidth of 4MHz and a minimum input referred noise of \30fA/V7lz. Power dissipation is 17.7mW.
Tumati, Raghu, "Solid-State Nanopore Characterization and Low noise Transimpedance Amplifier for Nanopore-Based Gene Sequencer" (2008). Electronic Theses and Dissertations. 950.