Date of Award
2008
Level of Access Assigned by Author
Campus-Only Thesis
Degree Name
Master of Arts (MA)
Department
Mathematics
Advisor
Ramesh C. Gupta
Second Committee Member
Pushpa L. Gupta
Third Committee Member
Henrik Bresinsky
Abstract
An important goal in quantitative risk/safety analysis of chemical toxins or pharmaceutical agents is determination of toxic risk posed by exposure to the agent. For purpose of assessing exposure risks, the extra risk function is defined as the risk above the background level corrected for non-response in the unexposed population. Our interest, in this thesis, is in statistical methods for obtaining upper confidence limits on the extra risk and lower confidence limits on the dose level at which a certain benchmark risk is achieved. Existing method on the above problem is examined and several examples from literature are provided. In addition, a new method of obtaining the desired confidence intervals is investigated and the results are compared with those obtained by the existing method.
Recommended Citation
Wang, Na, "Estimation of Extra Risk and Benchmark Dose in Dose Response Models" (2008). Electronic Theses and Dissertations. 1019.
https://digitalcommons.library.umaine.edu/etd/1019